More mystery than you know. You've probably encountered this spirit at some point in your life -- or at the very least have seen photos of Janis Joplin clutching a bottle in her hand -- but, have you ever stopped to think about what it is, exactly? Most people think of Southern Comfort as a whiskey. A look at Google's search trends shows "Southern Comfort Whiskey" as one of the more popular search terms. And the bottle of brown liquid often sits next to the whiskey at your local liquor store, but it is not in fact a whiskey. Or a bourbon. Or a Scotch. Don't let its golden color make a fool of you. Southern Comfort, which was first named Cuffs & Buttons, is in fact a liqueur -- a whiskey-flavored one.